Meditation, Yoga Might Switch Off Stress Genes

He believes that this study is the first comprehensive look at how mind states can affect gene expression. It also focuses on gene activity in healthy individuals.

Benson and his colleagues compared gene-expression patterns in 19 long-term practitioners, 19 healthy controls and 20 newcomers who underwent eight weeks of relaxation-response training.

More than 2,200 genes were activated differently in the long-time practitioners relative to the controls and 1,561 genes in the short-timers compared to the long-time practitioners. Some 433 of the differently activated genes were shared among short-term and long-term practitioners.

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Further genetic analysis revealed changes in cellular metabolism, response to oxidative stress and other processes in both short- and long-term practitioners. All of these processes may contribute to cellular damage stemming from chronic stress.

Another expert had a mixed response to the findings.

Robert Schwartz, director of the Texas A&M Health Science Center's Institute of Biosciences and Technology in Houston, noted that the study was relatively small. He also wished that there had been more data on the levels of stress hormones within the control group, for comparison purposes.

However, Schwartz called the study "unique and very exciting. It demonstrates that all these techniques of relaxation response have a biofeedback mechanism that alters gene expression."

He pointed out that the researchers looked at blood cells, which consist largely of immune cells. "You're getting the response most probably in the immune cell population," Schwartz said.

"We all are under stress and have many manifestations of that stress," Benson added. "To adequately protect ourselves against stress, we should use an approach and a technique that we believe evokes the relaxation response 20 minutes, once a day."

More information

There's more on meditation at the U.S. National Center for Complementary and Alternative Medicine.