Avandamet - Drug Description

Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

AVANDAMET is available for oral administration as tablets containing

rosiglitazone maleate and metformin hydrochloride equivalent to: 1 mg rosiglitazone with 500 mg metformin hydrochloride (1 mg/ 500 mg), 2 mg rosiglitazone with 500 mg metformin hydrochloride (2 mg/ 500 mg), 4 mg rosiglitazone with 500 mg metformin hydrochloride (4 mg/ 500 mg), 2 mg rosiglitazone with 1,000 mg metformin hydrochloride (2 mg/ 1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin hydrochloride (4 mg/ 1,000 mg).

In addition, each tablet contains the following inactive ingredients: Hypromellose 2910, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1 or more of the following: Red and yellow iron oxides.

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